Browsed by
Tag: Rural Health

Cancer Prevention Research Presented at ASPO

Cancer Prevention Research Presented at ASPO

Klein Buendel investigators and their collaborators presented research from two large studies at the 50th Annual Meeting of the American Society of Preventive Oncology on April 12-14 in Denver, Colorado. The theme of the conference was “50 Years of Impact: Empowering Communities Through Cancer Prevention Research.” 

*Klein Buendel authors are bolded.

ORAL PRESENTATION 1

Title: A Confederate Study of Indoor Tanning Facility Compliance with Laws

Presenter: Dr. Carolyn Heckman

Co-authors: Anna Mitarotondo, Melissa Goldstein, Rucha Janodia, Ileana Gonzalez, Dr. David Buller, Julia Berteletti

  • This submission was designated as a Best of ASPO Abstract.

Because indoor tanning is a known cause of skin cancer, state laws and federal regulations restricting indoor tanning for minors have been implemented: 22 states and the District of Columbia (DC) ban minors under age 18 from indoor tanning, 22 states have other age and parental involvement restrictions, and 6 states have no restrictions on minor access to indoor tanning. The assessed indoor tanning facility law compliance, hypothesized to be insufficient and inconsistent.

Trained and supervised pseudo-patrons called randomly selected indoor tanning facilities (indoor tanning salons, beauty salons/spas, gyms, apartment buildings) in 50 states and DC, posing as minors one year younger than the state’s permitted age to indoor tan (age 17 in states banning indoor tanning under 18) or age 16 in states with no age restriction. Using a semi-structured script, pseudo-patrons asked about scheduling an indoor tanning session, unlimited indoor tanning (contrary to FDA guidelines), risk of skin burns, and parental involvement requirements. Responses were coded, with discrepancies resolved by consensus, and summarized descriptively.

A total of 504 calls were completed to 206 indoor tanning salons, 111 gyms, 101 spas/beauty salons, and 86 apartment buildings. Overall, 55% of facilities would allow pseudo-patrons to book an appointment or “walk in” for indoor tanning, despite being underage, compared to 32% in states with under-18 bans. In states with minor restrictions, indoor tanning salons were least likely (48%) to permit minor indoor tanning and gyms, most likely to do so (56%). Twenty-six percent (26%) of staff did not ask pseudo-patrons their age, irrespective of law type. Forty-four percent (44%) of gyms/apartments did not require membership/tenancy to indoor tan. Most facilities (92%) offered unlimited indoor tanning packages or unlimited access to tanning beds when open. Only 52% of facility staff acknowledged that pseudo-patrons’ skin could be burned, when asked.

Although many states have laws restricting indoor tanning by minors, indoor tanning facilities were commonly non-compliant with age restrictions, suggesting inadequate law awareness and/or enforcement. Strategies must be identified to implement indoor tanning laws effectively and realize their benefits, including preventing skin burns, skin cancer, and other health consequences. Ongoing analyses are evaluating compliance when scheduling appointments online and by additional law provisions, state demographics, and U.S. region.

This research was supported by a grant to Rutgers University from the National Cancer Institute (CA244370; Dr. Carolyn Heckman and Dr. David Buller, Multiple Principal Investigators).

POSTER 1 

Title: Correlates of Human Papillomavirus Vaccination Among a Sample of Emerging Adults Aged 18-26 Living in Rural Locations in the Western United States

Presenter: Dr. David Buller

Co-authors:  Dr. Deanna Kepka, Dr. Echo Warner, Dr. Evelinn Borrayo, Dr. Andrew Sussman, Alishia Kinsey, Dr. W. Gill Woodall, Dr. David Buller

Dr. Borrayo, Dr. Buller and Dr. Warner

Human Papillomavirus (HPV) vaccination status and correlates were examined in a sample of emerging adults living in rural locations in the western United States. Eight hundred and ten (n=810) emerging adults residing in rural areas in 17 western U.S. states were recruited from online survey panels or by social media advertising from August 2024-2025 for a randomized trial. Emerging adults reported at baseline their HPV vaccine uptake status, including number of doses received. Using logistic regression analysis, we tested the association of demographics, attitudes, health care, and social media use with HPV vaccine uptake status (0=no/don’t know; 1=vaccinated) and vaccine doses received (0=0 or 1 dose/don’t know; 1=2 or 3 doses).

Overall, 424 (52.3%) rural emerging adults reported being vaccinated for HPV and 184 (22.7%) not being vaccinated, and 202 (24.9%) did not know. Of the 424 emerging adults vaccinated, 41 emerging adults (9.7%) recalled receiving one dose, 88 (20.7%) two doses, and 101 (23.8%) three doses of the vaccine, but 194 emerging adults (45.8%) did not know. More rural emerging adults who were vaccinated were female, more educated, attended religious services less frequently, had a personal/family history of cancer, were more confident vaccines are safe, and had less constraints on getting vaccinated. More rural emerging adults with multiple vaccine doses were older, female, visited a physician for a routine health check-up more recently, were more confident that vaccines are safe, and had less constraints on getting vaccinated.

Uptake of HPV vaccination among rural emerging adults (52.3%) was slightly higher than the national rate in the 2022 National Health Interview Survey (47.4%). Emerging adults need advice on how to confirm vaccination status (such as checking with parent, physician, or vaccine registry) when promoting catch-up HPV vaccination. HPV vaccination interventions should educate on vaccine safety/ constraints, how it can reduce personal/family cancer concerns, and religious groups that support it. Medical providers should offer HPV vaccination to emerging adults during routine health check-ups. Male and less educated emerging adults would benefit from intervention.

This research from the #4Corners4Health study was supported by a grant to Klein Buendel from the National Cancer Institute (CA268037; Dr. David Buller and Dr. Andrew Sussman, Multiple Principal Investigators). Other collaborators are from the University of Arizona, the University of Colorado, the University of Utah, and Colorado State University.

POSTER 2 

Title: Associations Between Food Insecurity and Dietary Intake and Nicotine Use Among Rural Emerging Adults in the Western United States

Presenter: Dr. Megan Skiba

Co-authors:  Dr. Doug Taren, Dr. Dolores Guest, Dr. Kim Henry, Dr. Judith Gordon, Noah Chirico, Dr. Echo Warner, Alishia Kinsey, Angela Jung, Dr. Andrew Sussman, Dr. David Buller

Dr. Skiba

The purpose of the study was to evaluate the associations between food insecurity, dietary intake, and tobacco/nicotine use among emerging adults aged 18-26 years living in rural areas of the western United States. 

This analysis used baseline data from 810 rural emerging adults participating in a randomized trial evaluating a social media-delivered cancer prevention intervention. Emerging adults completed self-report surveys assessing demographics, dietary intake (NCI Dietary Screener Questionnaire), and any nicotine product use (yes/no) in the past 30 days. Dietary measures included predicted intake of fruit and vegetable (servings/day), fiber (g/day), added sugar from sugar sweetened beverages (tsp/day), and red/processed meat (frequency/week). Food insecurity was categorized as very low food secure, low food secure, and high food secure from a single item measuring worry about running out of food before having money to buy more. Associations between food insecurity and dietary intake or tobacco/nicotine use were examined using linear or logistic regression models, adjusting for significant demographic covariates. Linear trend tests assessed graded relationships across food insecurity levels.

Of emerging adults (mean age 22.7 years), 62% reported low or very low food security. Food insecurity was associated with race, sex, education, and employment and were used as model covariates. A positive linear trend was observed between food insecurity and added sugar from sugar sweetened beverages, with very low food secure emerging adults consuming an average of 13.0 tsp/day from sugar sweetened beverages. There were no significant associations between food insecurity and fruit and vegetable, fiber, or red/processed meat intake, although fruit and vegetable and fiber intake were low overall (2.3 ± 0.6 servings/day and 15.1 ± 3.4 g/day, respectively). Percent of emerging adults using nicotine was greater with increasing levels of food insecurity: 24% among those with high food security, 41% among those with low food security, and 53% among those with very low food security. Odds increased 2.5 times for each stepwise increase in food insecurity.

Experiencing food insecurity may be a determinant of cancer-preventive health behaviors in rural emerging adults. Very low food security may be an important target for interventions aimed at improving multiple cancer preventive health behaviors among rural emerging adults.

This research from the #4Corners4Health study was supported by a grant to Klein Buendel from the National Cancer Institute (CA268037; Dr. David Buller and Dr. Andrew Sussman, Multiple Principal Investigators). Other collaborators are from the University of Arizona, the University of Colorado, the University of Utah, and Colorado State University.

Development of an Online Cancer Prevention Intervention for Rural Emerging Adults

Development of an Online Cancer Prevention Intervention for Rural Emerging Adults

A multi-state research team from Arizona, Colorado, New Mexico, and Utah has published research on a rural health intervention in the Journal of Medical Internet Research. The study developed and pilot tested a theory-based intervention via the web to reduce six cancer risk factors among rural emerging adults through community-engaged research.

The rapid growth of user-generated web-based health information increases the complexity of cancer information seeking. One promising strategy for promoting high-quality cancer information consumption is through targeted interventions that are intentionally designed to reach individuals in the online spaces they occupy. However, there is a paucity of evidence-based information on the best strategies for designing and implementing web-based health behavior change interventions to improve individuals’ cancer-related knowledge and prevent cancer.

This mixed methods approach describes the development of an online cancer prevention intervention aimed at rural emerging adults aged 18-26 years in the United States and delivered in Facebook private groups. The intervention was guided by behavior change theory and co-created with young adults and Stakeholder Organization Advisory Boards to ensure relevance, accessibility, and appropriateness. The paper reported on three formative surveys, a pilot intervention, protocol development, and the community-engaged process for intervention development.

The authors developed 400 posts for a Facebook feed aimed at reducing six cancer risk behaviors (unhealthy diet, lack of physical activity, tobacco use, alcohol use, sun exposure, and human papillomavirus infection) with iterative input from the emerging adults and stakeholder advisory boards. Formative surveys with rural 297 emerging adults and a pilot study of the intervention with this 26 people from this population were conducted. In the pilot study, the intervention reached a sample of participants across several rural counties, with sustained engagement over a one-month period. Key modifications to the intervention content and design emerged from both advisory boards, the formative surveys, and the pilot intervention, focusing on using perceived reliable sources and direct links to source material.

The authors concluded that this web-based cancer prevention intervention is scalable and delivers engaging, evidence-informed health information to rural emerging adults. They offered key insights into the design and implementation of web-based cancer prevention interventions for emerging adults by describing the resources, timelines, and expertise needed to design and implement the intervention. Considerations for fully engaging young people and community stakeholder partners are presented, and how their involvement resulted in modifications that strengthened the intervention was discussed. Finally, the authors highlighted the importance of theory-based health-behavior messaging, digital messaging skillsets, and platform-tailored dissemination strategies for maximizing web-based intervention acceptability.

The research is supported by a grant from the National Cancer Institute (CA268037; Dr. David Buller and Dr. Andrew Sussman, Multiple Principal Investigators). Dr. Buller is the Director of Research at Klein Buendel. Dr. Sussman is from the University of New Mexico Comprehensive Cancer Center. Other collaborating investigators are from the University of Utah, the University of Arizona, the University of Colorado, and Colorado State University. The lead author of the Journal of Medical Internet Research paper is Dr. Echo Warner from the College of Nursing and the Huntsman Cancer Institute at the University of Utah.

KB Research Presented at SBM – Part 1

KB Research Presented at SBM – Part 1

Dr. David Buller from Klein Buendel presented three posters at the 46th Annual Sessions and Meeting of the Society of Behavioral Medicine in San Francisco, California, March 26-29, 2025. Dr. Kayla Nuss and Ms. Julia Berteletti from Klein Buendel were co-authors on a fourth poster.

*Klein Buendel authors are bolded.

Dr. David Buller

Poster 1

Title: Economic Evaluation of Two Scalability Strategies for Nationwide Dissemination of an Occupational Sun Safety Intervention

Presenter: David Buller

Authors: Richard Meenan, David Buller, Julia Berteletti, Kimberly Henry, Mary Buller, Gary Cutter, Irene Adjei, and Noah Chirico

Americans spend many hours in work environments that contribute to health risks through hazardous job exposures. An economic evaluation of two methods for scaling up the Go Sun Smart at Work (GSS@W) evidence-based occupational sun protection program to prevent skin cancer in a nationwide transportation industry was conducted. GSS@W promoted employer adoption of sun protection policies and employee use of personal sun protection.

Cost-effectiveness analysis compared digital and in-person scalability strategies for disseminating the GSS@W program in a prospective two-group randomized trial. Regional districts (n=138) in 21 state Departments of Transportation (DOT) throughout the United States were recruited. District managers were assessed before and after scale-up and employees were posttest only. GSS@W was disseminated to managers at DOT districts either via an in-person scalability strategy with face-to-face on-site meetings and employee training or a digital scalability strategy with virtual meetings and online training. Cost of delivering GSS@W was obtained from project accounting records and manager reports on number and associated costs of implemented sun protection actions. Primary cost analysis was incremental cost-effectiveness ratio (ICER) between digital and in-person strategies, using program delivery cost as numerator and number of implemented sun protection actions as denominator. Secondary analysis summarized cost of implemented sun protection actions as reported by participating districts.

Mean implemented actions per district were 6.23 in digital and 6.53 in in-person strategy groups. Program delivery costs were estimated to be $15,658 for the digital strategy and $74,275 for the in-person strategy. Across all districts, the ICER was $3,305, representing average cost savings from an action not implemented under the digital strategy but implemented under the in-person strategy. Training was the most expensive action implemented by districts under either strategy (88% of implemented action costs).

The digital scalability strategy was cost-effective relative to an in-person strategy, generating substantial cost savings and offsetting a lower mean number of implemented GSS@W program actions. The GSS@W intervention may be readily implemented within employers that manage large annual budgets. Cost analysis was limited by not assessing induced costs to employees and potential feedback effects that could produce contamination.

The research was supported by a Cancer Moonshot Initiative grant from the National Cancer Institute (CA210259; Dr. David Buller, Principal Investigator). 

Poster 2

Title: Pilot Test of a Social Media Campaign on Preventing Cancer Risk Factors for Emerging Adults in Rural Communities in the American Mountain West

Presenter: David Buller

Authors: David Buller, Andrew Sussman, Echo Warner, Alishia Kinsey, Barbara Walkosz, Judith Gordon, W. Gill Woodall, Douglas Taren, Deanna Kepka, Kimberly L. Henry, Kayla Nuss, Cindy Blair, Evelinn Borrayo, David Wetter, Meghan Skiba, Julia Berteletti, Annelise Small, Dolores Guest, and John Torres

A social media campaign on preventing six cancer risk factors – being physical inactive, eating an unhealthy diet, using nicotine products, binging alcohol, being sunburned, and being unvaccinated for human papillomavirus (HPV) – was pilot-tested with emerging adults aged 18-26 living in rural counties.

Using an integrated theoretical framework, social media posts were developed to counter the cancer risk factors. Posts covered simplicity, benefits, response efficacy/cost, self-efficacy/perceived control, risk perceptions, norms, social support/relatedness, goals/values compatibility, intrinsic/extrinsic motivation, media literacy, and communication with family/friends. Twenty-six (26) emerging adults aged 18-26 living in rural counties in Arizona, Colorado, New Mexico, and Utah received a 4-week social media feed with 64 posts delivered in a private Facebook group. Emerging adults completed pretest and posttest surveys, and engagement (views, reactions, comments) was recorded.

Participants were 85% female and 35% Hispanic, with a median age of 23. At pretest, emerging adults demonstrated cancer risk factors: 53% engaged in <150 minutes of moderate-to-vigorous physical activity weekly, 85% had low daily intake of fruits and vegetables, 35% used nicotine products, 58% binged alcohol, 65% were sunburned, and 38% were unvaccinated for HPV. The campaign feed received 1,060 views, 346 reactions and 72 comments. Of the six cancer risk factors, posts on physical activity received the most views (216 views) while those on HPV and sun safety, the least (115 views each). Posts on physical activity, nicotine products, and alcohol received the most reactions (>50 reactions each) and physical activity and diet posts received the most comments (>9 comments each).

Social media is a popular source for health information among emerging adults. A multi-risk factor social media campaign has potential to engage emerging adults with theory-based cancer prevention messaging. The campaign will be evaluated in a randomized trial in 2025.

The research is supported by a grant from the National Cancer Institute (CA268037; Dr. David Buller and Dr. Andrew Sussman, Multiple Principal Investigators). Dr. Sussman is from the University of New Mexico Comprehensive Cancer Center. Other collaborating investigators are from the University of Utah, the University of Arizona, the University of Colorado, and Colorado State University.  

Poster 3

Title: Association of Indoor Tanning State Laws and Other Contextual Factors with Burns from Indoor Tanning in a National Sample of US Young Adults

Presenter: David Buller

Authors: Carolyn Heckman, David Buller, Anna Mitarotondo, Daniel Gundersen, Marisa Tomaino, and Julia Berteletti

Indoor tanning by minors is a significant risk factor for the development of melanoma. In addition to FDA safety regulations, 46 states restrict minor indoor tanning access by minors to prevent acute (burns from UV exposure) and chronic (skin cancer) harms. This study’s purpose was to identify state policy and other contextual factors associated with burns from indoor tanning to inform state policy efforts.

The authors conducted an online, nationally representative survey of individuals aged 18-29 who indoor tanned in the last three years (N=1000). Respondents reported on indoor tanning as adults (age 18 or older) and as minors (under age 18). Stringency of state laws on indoor tanning use by minors was scored, with no laws regulating minor indoor tanning being a “0” and laws banning all minors under 18 from indoor tanning being a “10.” Generalized linear models were used to estimate the associations of policy stringency for minor use and enforcement, indoor tanning behavior, and other contextual factors with burns after indoor tanning as a minor or adult. All analyses used the sampling weights.

Eighty-eight percent (88%) of participants reported engaging in indoor tanning in multiple facility types in the last three years, including indoor tanning salons, gyms, beauty salons, homes, spas, and apartments. Stringency of indoor tanning laws in participants’ home states were coded as an average of 4 (weak) out of 10. Fifty-seven percent (57%) of participants reported burning one or more times from indoor tanning in the past three years, with 14% from their most recent indoor tanning session. Correlates of burns from indoor tanning when a minor were weaker age restrictions, greater enforcement, more binge drinking, tanning at locales other than an indoor tanning salon, more sessions, shorter sessions, and more sunburns. Correlates of burns from indoor tanning when an adult were being between 22-25 years old, lower perceived indoor tanning facility safety in their state, greater enforcement, more sessions, and more sunburns.

This is the first study to investigate the impact of the stringency and enforcement of age restrictions in state indoor tanning law on burns both for indoor tanning before and after age 18, in a representative national sample. Burns were very common in the context of weak laws in many states, yet harmful burns after indoor tanning during childhood appeared to be lower in states with stronger age restrictions. Enforcing weak laws or inadequate safety regulations/compliance appears to have little impact on indoor tanning or burns in minors or adults. Thus, increasing stringency of state indoor tanning laws for all facility types may ultimately decrease acute harm and subsequent skin cancer rates.

This research was supported by a grant to Rutgers University from the National Cancer Institute (CA244370; Dr. Carolyn Heckman and Dr. David Buller, Multiple Principal Investigators).

Poster 4

Title: Social Comparison as a Behavior Change Technique in Digital Interventions: Users’ Perceptions of Leaderboards to Promote Physical Activity Motivation and Behavior

Presenters: Raj Harsora and Danielle Arigo from Rowan University

Authors: Raj Harsora, Emmanuel Lapitan, Giada Benasi, Amanda Folk, Laura König, Kayla Nuss, Julia Berteletti, Kyle R. Haggerty, and Danielle Arigo

Physical activity leaderboards are a common feature in digital health tools; they display users ranked physical activity behavior from highest to lowest, leveraging social comparison to boost motivation. However, some users find them motivating while others find them aversive. It is not clear how users interpret information from a leaderboard, or for whom or under what circumstances leaderboards might be effective.

To examine these nuances, we surveyed 1,676 adults in the United States and Europe (52% women). Of those who use physical activity apps, 8% indicated that their app has a leaderboard; 70% of these users did not participate in the leaderboard and expressed dislike of this feature for its emphasis on competition, unnecessary pressure, and potential “failure.” The remaining 30% reported using the leaderboard for 2 to 24 months because it kept them motivated by showing their success, particularly as they compared to others at the “same skill level.” After viewing a leaderboard with their own rank depicted, 63% of all respondents (1,504 adults) perceived themselves as doing well with physical activity. In a separate response, however, 51% perceived themselves as doing poorly. These perceptions differed by rank but also showed meaningful heterogeneity for the same rank. Across ranks, 74% of respondents endorsed motivation to engage in physical activity though 26% did not. Physical activity motivation did not differ by rank and was not associated with perceiving oneself as doing poorly but was positively associated with perceiving oneself as doing well; the latter was strongest for those ranked 3rd of 6.

Finally, physical activity motivation in response to the leaderboard did not differ by gender but was higher among those with stronger (vs. weaker) general tendencies to respond positively and negatively to comparison opportunities; the latter did not differ by rank. Findings show that responses to physical activity leaderboards vary widely and aren’t based solely on rank or individual difference characteristics. Further, some people who believe they dislike leaderboards still find them motivating, and it is unclear how leaderboards affect physical activity behavior in daily life. Additional investigation is warranted to identify for whom and under what circumstances leaderboards are most likely to lead to benefits for physical activity.

This research was funded by an NIH Director’s New Innovator Award to Rowan University (DP2HL173857; Danielle Arigo, Principal Investigator).

STAC-T Usability Testing Results

STAC-T Usability Testing Results

A research team from Boise State University and Klein Buendel have published a paper in JMIR Human Factors entitled, “Usability Testing of a Bystander Bullying Intervention App (STAC-T) for Rural Middle Schools: A Mixed-Methods Study.” The paper reports on the conduct and outcomes of the usability testing of a bystander bullying intervention app for rural middle school students.

Students who are targets of bullying are at high risk for negative mental health outcomes including depression, anxiety, and suicidal ideation. Implementing school-based bullying prevention programs reduces bullying. Bullying prevention programs are particularly important in rural schools, as bullying is more prevalent in rural schools compared to urban schools. Comprehensive, school-wide bullying prevention programs, however, require resources that create significant barriers to implementation for rural schools. Because technology-based programs can reduce some of these implementation barriers, the development of a technology-based program to address bullying increases access to bullying prevention for students in rural settings.

This study assessed the usability and acceptability of the STAC-T app and differences in usability between school personnel and students. Qualitative feedback related to usability, program features, and feasibility was also obtained and analyzed. A sample of 21 participants (10 school personnel and 11 students) recruited from two middle schools in rural, low-income communities in two states completed usability testing followed by a qualitative interview. We used descriptive statistics and independent sample t-tests to assess usability and program satisfaction. We used consensual qualitative research (CQR) as a framework to extract themes related to usefulness, relevance, needs, barriers, and feedback for intervention development.

Usability testing indicated the app was easy to use, acceptable, and feasible. Both school personnel and students rated the app well above the standard cutoff score for above-average usability (68.0) and both school personnel and students gave the app high user-friendliness ratings (0-7 scale, with 7 high user-friendliness). Overall ratings also suggested school personnel and students were satisfied with the program. Among school personnel, 100% said they would recommend the program to others and 10%, 50%, and 40% rated the program as 3, 4, and 5 stars, respectively. Among students, 90.9% said they would recommend the program to others and 27.3% and 72.7% rated the program as 4 stars and 5 stars, respectively. There were no statistically significant differences in ratings between school personnel and students.

Qualitative data revealed that both school personnel and students found the STAC-T app useful, relevant, and appropriate, while providing feedback related to the importance of narration of the text and the need for teacher and parent trainings to accompany the student program. Data also showed school personnel and students would find a tracker useful, in which students could report the different types of bullying they witnessed and strategies they used to intervene. Data from school personnel also indicated the program was perceived as practical and very likely to be adopted by schools, with time, cost, and accessibility being noted as potential barriers for schools in rural communities. The results demonstrate high usability and acceptability of the STAC-T app and provide support for implementing a full-scale randomized controlled trial to test the efficacy of STAC-T.

This research is funded by an STTR Phase II grant to Klein Buendel from the National Institute on Minority Health and Health Disparities at the National Institutes of Health (MD014943; Dr. Aida Midgett, Principal Investigator, Boise State University). Co-authors include Dr. Diana Doumas, Dr. Claudia Peralta, and Dr. Blaine Reilly from Boise State University; Dr. Matthew Peck from the University of Arkansas; and Ms. Mary Buller from Klein Buendel. The STAC-T modules were graphically designed and programmed by Klein Buendel’s Creative Team.

KB Scientists Present HPV Vaccination Research

KB Scientists Present HPV Vaccination Research

Two Klein Buendel scientists presented HPV vaccination research at the 36th International Papillomavirus Conference in Edinburgh, Scotland, November 12-15, 2024.

Poster 1

Title: HPV Vaccine Uptake Improvement for Adolescent Boys via a Mobile Web App:  TeenVac.org

Presenter: W. Gill Woodall, PhD

Authors: W. Gill Woodall, PhD; David Buller, PhD; Gregory Zimet PhD; Alberta Kong, MD, MPH; Jeannyfer Reither, MS; Lance Chilton, MD; Lila Martinez; Marita Brooks, MS; Noah Chirico, MPH; Tamar Ginnosar, PhD

Dr. Gill Woodall

Human Papillomavirus (HPV) vaccine uptake remains below the U.S. national goal of 80% series completion. Parental concerns and misinformation about the HPV vaccine’s efficacy and safety remain and may be addressed by digital interventions tailored to their concerns.

Based on a previous intervention focused on parents and adolescent daughters, a randomized controlled trial was conducted testing a mobile web app (TeenVac.org) for parents and their adolescent sons (ages 11-14 years), responsive to their concerns and encouraging HPV vaccination. Two hundred nine (209) participants were randomized to receive either the TeenVac app (n=100) or the standard CDC HPV vaccination pamphlet (n=109) online. Adolescent sons’ vaccination records were collected from the New Mexico vaccine registry at the end of the study.

Intent-to-treat and web usage analyses were conducted. Intent-to-treat analyses found that adolescent sons of parents who were randomized to the TeenVac app were significantly more likely to complete the HPV vaccination series than the CDC pamphlet comparison group. Web usage analysis determined that those parents in the TeenVac group who used the web app were significantly more likely to complete the HPV vaccination series than those in the CDC pamphlet group. Modules focused on nature of HPV, the vaccine, and who recommends it were most used, with average durations ranging from 84 to 122 seconds.

The TeenVac app had a meaningful impact on HPV vaccine shot completion, particularly among parents who used the web app. The study trial’s recruitment and implementation were affected by the COVID-19 pandemic, with 86% of parent-adolescent pairs recruited during this period. Despite these challenges, the results provide further evidence that digital interventions can improve vaccine uptake when focused on parents and sons’ vaccine-related concerns.

This research was funded by a grant from the National Cancer Institute (CA210125; Dr. W. Gill Woodall, Principal Investigator). Collaborators were from the University of New Mexico, Indiana University, and Klein Buendel.

Poster 2

Title: Development of Social Media Posts Promoting HPV Vaccination to Emerging Adults in Rural Communities of the united States

Presenter: David Buller, PhD

Authors: David Buller, PhD; Andrew Sussman, PhD; Echo Warner, PhD; Alishia Kinsey; W. Gill Woodall, PhD; Deanna Kepka, PhD; Barbara Walkosz, PhD; Julia Berteletti, MSW; Annelise Small; Dolores Guest, PhD; John Torres

Dr. David Buller

HPV-related cancers are increasing in rural areas of the United States and HPV vaccination rates of emerging adults are low. A social media campaign promoting HPV vaccine uptake, along with five other cancer risk-reduction behaviors, is being developed for emerging adults aged 18-26 living in rural counties in the western United States. Campaign posts were pilot-tested with emerging adults (n=188) in surveys on appropriateness, relevance, and trustworthiness and likelihood of engaging with them (such as read, scroll past, react [such as like, sad, etc.], comment, and click on a shared link). Also, emerging adults (n=26) were enrolled in a 4-week study where they received HPV vaccination posts in a Facebook private group and engagement (such as views, reactions, comments) was recorded.

Initially, 36 posts on HPV vaccination were developed addressing simplicity, benefits, response efficacy/cost, self-efficacy/perceived control, cancer risk perceptions, norms, relatedness, compatibility with goals/values, and intrinsic/extrinsic motivation. Posts debunked common misinformation on HPV vaccines, stressed that unvaccinated emerging adults should get vaccinated, and advised emerging adults on how to discuss HPV vaccination with family and friends. Emerging adults evaluated seven HPV vaccination posts in the surveys and rated them as appropriate, relevant, and trustworthy. Two-thirds of emerging adults said they would read the posts, but also might scroll past them. Over one-third would click on a shared link or leave a reaction, but few would comment. In the 4-week study, seven HPV vaccination posts received 115 views, 26 reactions, and 2 comments (both positive).

Social media is a primary health information source for young adults. Posts promoting HPV vaccination based on health behavior theories can reach and engage emerging adults with HPV vaccine-supportive messaging. The HPV posts will be included in a cancer prevention campaign evaluated in a randomized trial enrolling 1000 emerging adults in 2025.

This research was funded by a grant from the National Cancer Institute (CA268037; Dr. David Buller and Dr. Andrew Sussman, Multiple Principal Investigators). Collaborators were from the University of New Mexico Comprehensive Cancer Center, the University of Utah Huntsman Cancer Institute, and Klein Buendel.

EUROGIN HPV Panel Presentation

EUROGIN HPV Panel Presentation

Klein Buendel Senior Scientists, Dr. W. Gill Woodall and Dr. David Buller, presented two research projects in a panel discussion at the EUROGIN International Multidisciplinary HPV Congress on Feb 8-11, 2023 in Bilbao, Spain. The “Digital Interventions to Increase HPV Vaccination” panel featured four presentations and was moderated by Dr. Greg Zimet from the University of Indiana. Other Klein Buendel scientists and staff (at the time of abstract submission) contributing as co-authors included Dr. Barbara Walkosz, Ms. Marita Brooks, Ms. Lila Martinez, and Ms. Jeanny Reither. Klein Buendel employees’ names are bolded.

Presentation 1

Title: “Randomized Trials of HPV Vaccine Uptake Improvement: Web Apps for Parents and Young Adolescent Girls and Boys”

Presenter: W. Gill Woodall, PhD, Senior Scientist, Klein Buendel, Inc. Albuquerque, NM, USA

Co-authors: A. Kong, G. Zimet, D. Buller, L. Chilton, J. Reither, L. Martinez, M. Brooks

This presentation discussed the results of two randomized trials of parent-focused web apps to improve HPV vaccine uptake for young adolescents (ages 11-14).  For the first trial, the web app was tailored to parents and young adolescent girls, and in the second trial, the web app was tailored to parents and young adolescent boys. Results of both trials indicated significant web app impact on HPV vaccine uptake for adolescent girls and boys, as well as other vaccine uptake related variables.  The discussion included a consideration of web app content and tailoring to determine HPV vaccine uptake improvement.

Presentation 2

Title: “Successful technology-based rural patient HPV vaccination reminder intervention and social media assessment of strategies to reduce HPV vaccine misinformation”

Presenter: Deanna Kepka, PhD, MPH, University of Utah, Salt Lake City, UT, USA

Co-authors: K. Christini, E. McGough, B. Gibson, E. Warner, H. Brandt

This presentation described a multi-level and multi-component intervention that included healthcare team training activities and technology-based HPV vaccination reminders. Missed opportunities for HPV vaccination declined significantly from the pre-intervention to the post-intervention period. Participants who recalled receipt of an electronically delivered vaccination reminder had higher unadjusted odds of scheduling a visit compared with those who did not recall receiving a reminder. Social media-delivered misinformation related to HPV vaccination is pervasive. The presenters also discussed new strategies to evaluate and reduce the impact of HPV vaccine misinformation in rural settings.

Presentation 3

Title: “Promoting HPV vaccination to emerging adults in rural communities in a multi-risk factor cancer prevention social media intervention”

Presenter: David Buller, PhD, Senior Scientist, Klein Buendel, Inc., Denver, CO, USA

Co-authors: A. Sussman, D. Kepka, W. G. Woodall, E. Warner, B. Walkosz

This presentation described an innovative social media campaign targeting six cancer risk factors, including HPV vaccination. It is being developed for the diverse population of adults aged 18-26 in rural counties in the Mountain West region of the U.S. Emerging adults obtain health information online far more than information from health care providers and other media. A framework for social media message development was presented based on social cognitive, self-determination, and diffusion of innovation theory. Misinformation, especially on vaccination, will be combatted by instructing emerging adults in digital and media and by using an epidemiological model of monitoring and quickly responding to correct misinformation. The campaign will be tested with a sample of 1000 emerging adults in a stepped-wedge quasi-experimental design.

Presentation 4

Title: “U.S. National Digital Point of Care Communication to Improve Uptake of HPV and Other Adolescent Vaccines in Clinic Settings”

Presenter: Judy Klein, BA, BS, President, UNITY Consortium, Philadelphia, PA, USA

Co-authors: G. Zimet, V. Agadi, C. Hu, A. Jaramillo

This presentation reported on a study that involved digital targeted adolescent vaccination infographics and videos widely disseminated to clinical practices throughout the U.S. Over 11,000 clinicians whose practices received these digital interventions (exposed condition) were matched to an equal number of non-exposed comparison practices matched on multiple practice characteristics. The outcomes of interest were the number of vaccine doses (Tetanus-diphtheria-pertussis booster or Tdap, HPV, MenACWY, and MenB) administered to patients 11-18 years of age. The exposed clinics showed significant increases in administration of adolescent vaccines, including HPV vaccine, compared to the non-exposed clinics.

Collaborator Spotlight:
Dr. Andrew Sussman

Collaborator Spotlight:
Dr. Andrew Sussman

Dr. Andrew Sussman

Andrew Sussman, Ph.D., MCRP, is an Associate Professor in the Department of Family and Community Medicine at the University of New Mexico (UNM) and the Associate Director of the Office of Community Outreach and Engagement at the UNM Cancer Center. He received his Ph.D. from the University of New Mexico.

Dr. Sussman focuses his research efforts on primary health and cancer care delivery research and patient-provider counseling dynamics among health disparity populations in New Mexico. He also has research interests in clinical decision making, health service delivery, community-based participatory research, and health disparities in community settings. He also has expertise in qualitative and mixed method research, formative assessment, and process evaluation.

Currently, Dr. Sussman is serving as a Multiple Principal Investigator along with Klein Buendel’s Dr. David Buller on the study, #4Corners4Health: A Social Media Cancer Prevention Program for Rural Emerging Adults (CA268037). This study aims to aid rural emerging adults (aged 18-26 years) in making informed decisions that reduce cancer risk factors and prevent cancer later in life and help emerging adults evaluate and resist misinformation and marketing that promote cancer risk behaviors. This will be accomplished using a social media campaign designed with community advisors for diverse young adults living in rural counties in the Four Corners states (AZ, CO, NM, and UT). Social media may reach emerging adults more than interventions through other community channels (for example, clinics, schools, and workplaces) and for lower cost in the geographically-dispersed, underserved rural communities in the Mountain West.

#4Corners4Health

#4Corners4Health

A collaborative team of highly-experienced cancer prevention and control investigators from the Four Corners Cancer Centers Collaborative (University of Arizona, University of Colorado, University of New Mexico, and University of Utah), Colorado State University, and Klein Buendel is launching a research study that focuses on decreasing cancer risk factors among emerging adults (ages 18-26) living in rural counties in the “Four Corners” states (Arizona, Colorado, New Mexico, and Utah) using a social media campaign. Cancer risks related to infrequent physical activity, unhealthy diet, nicotine product use, alcohol intake, ultraviolet radiation exposure and lack of HPV vaccination are prevalent among emerging adults and contribute to cancer later in life.

The project will test a theory-based, multi-risk factor social media approach to cancer prevention through the use of Facebook and its private group function. Social media can improve information dissemination, credibility, and relevance, be used to detect and respond to emerging trends, and engage users with user-generated content that personalizes information. It offers a superior intervention for emerging adults compared to health care, schools, and workplaces which can be challenging to implement in low-resourced rural communities and will not reach many emerging adults who have low preventive health care utilization, school enrollment, and/or employment.

#4Corners4Health Specific Aims

  • Develop a social media intervention for diverse emerging adults in rural communities via a community-engaged process that combines expert advice, user-generated content, and online instruction about behavioral cancer risks, cancer misinformation, counter marketing, digital and media literacy, and family communication.
  • Evaluate the effect of a theory-based social media intervention on moderate to vigorous physical activity (MVPA), health eating patterns, nicotine product use, alcohol intake, sunburn prevalence, and HPV vaccination with the diverse (ethnically/ socioeconomically) population of emerging adults aged 18-26 in rural counties in the Four Corner states recruited from Qualtrics’ survey panel and enrolled in a pragmatic randomized trial using a stepped-wedge design in which individual emerging adults will be randomized to one of four cohorts and receive social media feed for varying durations in separate Facebook private groups.
  • Test if improvements in merging adults cancer risk knowledge and beliefs, digital and media literacy skills, accurate cancer prevention information, and family communication mediate impact of the social media campaign.
  • Explore whether the impact of the social media campaign differs according to a) level of emerging adults engagement with campaign, b) cancer risk factors, and c) biological sex of the participants.

The investigators hypothesize that (1) emerging adults will increase MVPA and healthy eating pattern, reduce nicotine product and alcohol use, and sunburns, and increase HPV vaccine uptake from pre to post when receiving social media campaign, and (2) positive impact of the social media campaign on cancer risk factors among emerging adults will be mediated by improved cancer risk knowledge and beliefs (self-response efficacy; norms; social support; vaccine antecedents), digital and media literacy skills, misinformation, and family communication.

This research will be led by Dr. David Buller from Klein Buendel and Dr. Andrew Sussman from the University of New Mexico (Multiple Principal Investigators). It is being funded by a 5-year R01 grant from the National Cancer Institute (CA268037). Key collaborators include Dr. Kimberly Henry from Colorado State University; Dr. Cindy Blair from the University of New Mexico; Dr. Judith Gordon, Dr. Cynthia Thomson, and Dr. Jennifer Hatcher from the University of Arizona; Dr. Evelinn Borrayo and Dr. Douglas Taren from the University of Colorado; Dr. Deanna Kepka, Dr. Echo Warner, and Dr. David Wetter from the University of Utah; and Dr. Gill Woodall, Dr. Barbara Walkosz, Dr. Kayla Nuss, and Ms. Julia Berteletti from Klein Buendel.